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drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and or selection of Codeine works by weakly binding to a specific opioid receptor, known as the mu-opioid receptor, but with much less affinity than morphine, which means its analgesic (pain-relieving effects) are much less Codeine belongs to the drug class called opioids or opioid analgesics It may also be called a narcotic analgesic 2 UpsidesThe effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex Use of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine sulfate requires careful consideration of the effects on the parent drug, codeine, and the active metabolite, morphine go drugbank com drugs DB00318Codeine guaifenesin is a controlled substance because it can be misused or lead to dependence Store codeine guaifenesin in a safe place to protect it from theft It is illegal to sell or give Drug Interactions for Codeine Phosphate Codeine in combination with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects When s c combination therapy is contemplated, the dosage of one or both agents should be reduced Sep 12, 2023 · Codeine has been reported to have an apparent volume of distribution of approximately 3-6 L kg, indicating extensive distribution of the drug into tissues Codeine has low plasma protein binding with about 7-25% of codeine bound to plasma proteins Metabolism --- drugs com tips codeine-patient-tips Codeine is an oral prescription opioid (narcotic) drug most commonly used to treat mild-to-moderate pain, as a cough suppressant, and to help relieve pain from tension headaches It is often combined with other medications for these or other uses and can be habit-forming Apr 9, 2025 · The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex Use of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine sulfate requires careful consideration of the effects on the parent drug, codeine , and the active metabolite, morphine --- rxlist com codeine-phosphate-drug htm
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